BioChem.Examples.CaOscillations.Cytosol

# .BioChem.Examples.CaOscillations.Cytosol

## Information

# Ca Oscillations

This example is a Modelica version of the model presented in A Minimal Generic Model of Bacteria-Induced Intracellular Ca2+ Oscillations in Epithelial Cells by Camilla Oxhamre, Agneta Richter-Dahlfors, Vladimir P. Zhdanov, and Bengt Kasemoy. (Biophysical Journal Volume 88 April 2005 2976-2981)

## Abstract

The toxin &alpha-hemolysin expressed by uropathogenic Escherichia coli bacteria was recently shown as the first pathophysiologically relevant protein to induce oscillations of the intracellular Ca2+ concentration in target cells. Here, we propose a generic three-variable kinetic model describing the Ca2+ oscillations induced in single rat renal epithelial cells by this toxin. Specifically, we take into account the interplay between 1), the cytosolic Ca2+ concentration; 2), IP3-sensitive Ca2+ channels located in the membrane separating the cytosol and endoplasmic reticulum; and 3), toxin-related activation of production of IP3 by phospholipase C. With these ingredients, the predicted response of cells exposed to the toxin is in good agreement with the results of experiments.

## Simulations

The simulation results are shown in the Figure 1. This plot corresponds to Fig 1C of the paper (Oxhamre 2005).

## Contents

Name | Description
--- | ---
Ca_Cyt_ |
Jpump_ |

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